Project Description

Title: HIV Evolving Sites Visualization

Team members:

Liusu Wang: liusuw@uw.edu
Kuangyou Yao: kuangyou@uw.edu
CSE 512, University of Washington

Summary image:

Abstract:

This project is to create a visualization tool in aid of studying one of the deadliest viruses known to mankind, the Human immunodeficiency virus, commonly known as HIV. HIV is a retrovirus, which has certain features making it difficult to treat and eradicate including a high mutation rate. Hypotheses suggest that it is because their immune system recognize virus through a specific region of the virus shell protein that cannot tolerate mutations very well. Therefore, it is of interest to discover parts in the virus, which are crucial to virus replication. This information could be critical to informing effective vaccine strategies. The project is also projected to support other kinds of virus evolution which might shows similar pattern as HIV. In addition, The project provides a basis for additional features like providing meta-data about the mutations e.g. to determine if they are in T cell epitopes or immune escapes, or providing a more integrated comparison of multiple patients.

Links:

paper, poster, code

Running instructions:

You can view our visualization by visiting http://cse512-15s.github.io/fp-liusuw-kuangyou/ Alternatively, download this repository and run server.js and access this from http://localhost:8080/index.html